Dementia is a growing concern worldwide, affecting millions of people each year. The statistics are stark: 2 in every 100 people between the ages of 65 and 69 have dementia, and the risk doubles every five years. By the time you're over 90, that risk skyrockets to 1 in 3 Alzheimer's Society.
But there's hope. Recent research published in The Lancet has uncovered 14 powerful strategies to reduce the risk of dementia by up to 45% The Lancet. These strategies are based on the latest scientific findings and offer practical steps that can be taken at any age.
Let's dive into these 14 strategies, starting with the foundation of a healthy brain: education and cognitive stimulation.
Table of Contents
- The Power of Education and Cognitive Stimulation
- Protecting Your Brain: The Importance of Hearing
- Vision Health and Dementia Risk
- Mental Health Matters: Depression and Dementia
- Exercise: Building and Protecting Brain Volume
- Preventing Head Injuries: Safety First
- The Impact of Smoking on Brain Health
- LDL Cholesterol and Dementia: What You Need to Know
- Weight Management and Diabetes: Crucial Factors
- Blood Pressure Control: A Key to Brain Health
- Alcohol Consumption: Balancing Risks
- Social Connections and Mental Health
- Reducing Exposure to Air Pollution
- Emerging Factors and Future Strategies
- Conclusion: Taking Action Now
- References
The Power of Education and Cognitive Stimulation
Education is often seen as a tool for personal and professional development, but its benefits extend far beyond that. Lifelong learning and cognitive stimulation play a crucial role in building what scientists call "cognitive reserve," which helps the brain resist damage from diseases like dementia.
A landmark study involving over 107,000 people found that those with high cognitive stimulation at work had a lower risk of dementia compared to those with low cognitive stimulation. Interestingly, even those with limited formal education but high cognitive engagement at work reduced their dementia risk by 20%. For those with both high cognitive stimulation and high education, the risk was reduced by an impressive 37% The Lancet.
Cognitive reserve is thought to act as a buffer, allowing the brain to compensate for damage by utilizing alternative neural pathways or networks. This reserve can be built and maintained through activities that challenge the mind, such as puzzles, learning new languages, playing musical instruments, and engaging in complex problem-solving tasks.
For adults, continuing education and pursuing hobbies that require mental effort can be particularly beneficial. For example, enrolling in online courses, participating in book clubs, or learning new skills like coding or photography can all contribute to cognitive resilience.
Additionally, staying mentally active through social interactions and volunteering can provide cognitive benefits. Engaging in conversations, teaching others, or mentoring can stimulate the brain and help maintain cognitive functions. The key is to keep the brain engaged and challenged, regardless of age.
Protecting Your Brain: The Importance of Hearing
Hearing is a critical sense that connects us to the world and plays a vital role in our cognitive health. As we age, the risk of hearing loss increases, with approximately 20% of people experiencing some degree of hearing impairment globally. Unfortunately, untreated hearing loss doesn't just impact communication; it also contributes to cognitive decline.
A pivotal study found that untreated hearing loss is associated with up to a 2.4 times higher risk of developing dementia The Lancet. For every 10 decibels of hearing loss, the risk of dementia increases by 24% The Lancet.
The connection between hearing loss and dementia may be due to several factors. When hearing diminishes, the brain receives less auditory input, leading to changes in brain structure and function. Additionally, hearing loss often leads to social isolation, which is another risk factor for cognitive decline.
The good news is that using hearing aids can significantly reduce the risk of cognitive decline. A systematic review found that people with hearing loss who used hearing aids had a lower risk of dementia compared to those who did not The Lancet.
Regular hearing check-ups are crucial, especially for older adults. Early detection and intervention can help mitigate the cognitive effects of hearing loss. Additionally, protecting your hearing by avoiding prolonged exposure to loud noises, using ear protection in noisy environments, and maintaining good ear hygiene can prevent hearing loss.
Vision Health and Dementia Risk
Just as hearing is vital for cognitive health, so too is vision. Our eyes are our windows to the world, and any impairment in vision can significantly impact our cognitive functions. A major meta-analysis that examined 14 studies involving over 6 million older adults found that those with vision loss had a 47% higher risk of developing dementia The Lancet.
Vision and cognitive health are closely intertwined. Visual impairment can lead to social isolation, depression, and a decrease in cognitive engagement, all of which contribute to dementia risk. Moreover, the brain regions responsible for processing visual information are also involved in other cognitive processes, making vision a crucial aspect of overall brain health.
To maintain good vision, regular eye examinations are essential. Early detection of common eye conditions such as cataracts, glaucoma, and age-related macular degeneration (AMD) can prevent or delay vision loss. Treatment options like corrective lenses, medications, or surgeries can restore or preserve vision, thereby reducing dementia risk.
In addition to regular check-ups, adopting a diet rich in eye-friendly nutrients is crucial. Foods high in antioxidants, such as leafy green vegetables, carrots, and omega-3 fatty acids, support eye health. Protecting your eyes from harmful UV rays by wearing sunglasses and reducing screen time to prevent digital eye strain are also important preventive measures.
Furthermore, engaging in activities that stimulate both visual and cognitive functions, such as reading, puzzles, and arts and crafts, can help maintain brain health. These activities keep the brain's visual processing centers active and engaged, promoting cognitive resilience.
Mental Health Matters: Depression and Dementia
Depression is a significant risk factor for dementia, yet it is often overlooked in discussions about cognitive health. Research shows that individuals with depression have more than double the risk of developing dementia compared to those without depression The Lancet. This risk is particularly pronounced in midlife, but it can affect individuals at any age.
The relationship between depression and dementia is complex and multifaceted. Chronic depression can lead to increased levels of stress hormones like cortisol, which can damage the brain over time. Depression also often results in reduced social interaction and physical activity, both of which are critical for maintaining cognitive health.
Treating depression is crucial for reducing the risk of dementia. A variety of treatments are available, including medications, psychotherapy, and lifestyle changes. Antidepressants can help regulate mood and cognitive function, while cognitive-behavioral therapy (CBT) provides tools to manage negative thought patterns and behaviors.
Additionally, lifestyle changes such as regular exercise, a healthy diet, and mindfulness practices like meditation can help alleviate symptoms of depression and improve overall mental health. Exercise, in particular, has been shown to have antidepressant effects by boosting endorphins and promoting neuroplasticity.
Social support is also a vital component of mental health. Building and maintaining strong relationships with family, friends, and community members can provide emotional support and reduce feelings of isolation and loneliness. Engaging in social activities, volunteering, or joining support groups can foster a sense of belonging and purpose.
Finally, early intervention is key. If you or someone you know is experiencing symptoms of depression, seeking help from a healthcare provider is crucial. Early treatment can not only improve quality of life but also reduce the long-term risk of dementia.
Exercise: Building and Protecting Brain Volume
Exercise is often hailed as a cornerstone of physical health, but its benefits for brain health are equally impressive. Regular physical activity has been shown to increase brain volume, enhance cognitive function, and reduce the risk of dementia The Lancet.
The benefits of exercise for the brain are multifaceted. Physical activity improves blood flow to the brain, delivering oxygen and nutrients that support neuronal health and function. Exercise also stimulates the release of neurotrophic factors, which promote the growth and survival of neurons, enhancing brain plasticity and resilience.
Different types of exercise offer unique benefits for brain health. Aerobic exercises, such as walking, running, swimming, and cycling, are particularly effective at improving cardiovascular health, which is closely linked to brain health. Resistance training, such as weightlifting, helps build and maintain muscle mass, which supports overall health and mobility in older adults.
Yoga and tai chi are also beneficial for brain health, as they combine physical movement with mindfulness and relaxation. These practices help reduce stress and anxiety, improve balance and coordination, and promote mental clarity.
For those new to exercise or looking to increase their activity levels, starting with moderate-intensity activities such as brisk walking or swimming can be a good approach. The key is consistency; aim for at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity exercise per week, along with muscle-strengthening activities on two or more days per week.
In addition to structured exercise, incorporating more movement into daily routines can have a significant impact. Simple actions like taking the stairs instead of the elevator, walking or cycling to work, and engaging in active hobbies like gardening or dancing can all contribute to better brain health.
Regular exercise not only helps reduce the risk of dementia but also enhances mood, reduces stress, and improves overall quality of life. Whether you're 30 or 90, it's never too late to start reaping the cognitive benefits of physical activity.
Preventing Head Injuries: Safety First
Head injuries are a well-documented risk factor for dementia, particularly traumatic brain injuries (TBIs). A meta-analysis involving over 7 million people found that those who experienced a TBI had a 66% higher risk of developing dementia later in life The Lancet.
Even mild traumatic brain injuries, such as concussions, can have long-term effects on brain health. Repeated head injuries, often seen in contact sports like rugby, football, and boxing, are particularly concerning. These injuries can lead to Chronic Traumatic Encephalopathy (CTE), a neurodegenerative condition linked to cognitive decline and dementia.
Preventing head injuries is essential for protecting brain health. For athletes and individuals involved in high-risk activities, wearing appropriate protective gear, such as helmets, is crucial. Adhering to safety guidelines and rules in sports can also reduce the risk of injury.
For older adults, preventing falls is a key aspect of reducing the risk of head injuries. Falls are the leading cause of TBIs in older adults, often resulting in serious consequences. Implementing fall-prevention strategies, such as improving home safety by removing tripping hazards, installing grab bars in bathrooms, and ensuring adequate lighting, can make a significant difference.
Engaging in balance and strength training exercises can also help prevent falls. Activities like yoga, tai chi, and specific strength exercises improve balance, coordination, and muscle strength, reducing the likelihood of falls.
Finally, staying vigilant about head safety in everyday activities is important. Whether you're biking, skiing, or simply walking on icy sidewalks, taking precautions to protect your head can help preserve cognitive health and reduce the risk of dementia.
The Impact of Smoking on Brain Health
Smoking is widely recognized as a major risk factor for various health issues, including cardiovascular disease, respiratory problems, and cancer. However, its impact on brain health, particularly its role in increasing the risk of dementia, is often underestimated.
A comprehensive 32-year study from the Whitehall II cohort revealed that current smokers had a significantly higher risk of dementia compared to those who never smoked. Interestingly, ex-smokers did not have an increased risk, highlighting the benefits of quitting smoking at any stage of life The Lancet.
The harmful effects of smoking on the brain are primarily due to the chemicals in tobacco smoke, which cause oxidative stress and inflammation. These processes damage brain cells and contribute to the buildup of amyloid plaques and tau tangles, both of which are hallmarks of Alzheimer's disease. Smoking also narrows blood vessels, reducing blood flow to the brain and increasing the risk of strokes and vascular dementia.
The good news is that quitting smoking can significantly reduce these risks. Within a few years of quitting, the body begins to repair the damage caused by smoking, including improvements in lung function, cardiovascular health, and blood circulation to the brain. Former smokers can expect to see a gradual decrease in their dementia risk over time, eventually reaching levels similar to those who never smoked.
Quitting smoking is challenging, but numerous resources and strategies can help. Nicotine replacement therapies (NRTs), such as patches, gum, and lozenges, can ease withdrawal symptoms and cravings. Prescription medications, like varenicline (Chantix) and bupropion (Zyban), can also support smoking cessation by reducing cravings and withdrawal symptoms.
Behavioral support, including counseling and support groups, can provide the motivation and encouragement needed to quit smoking. Many healthcare providers offer smoking cessation programs that combine medication with behavioral therapy, significantly increasing the chances of success.
Ultimately, quitting smoking is one of the most effective steps you can take to protect your brain health and reduce your risk of dementia. It's never too late to quit, and the benefits are both immediate and long-lasting.
LDL Cholesterol and Dementia: What You Need to Know
For many years, the relationship between cholesterol and brain health was unclear. However, recent research has provided a clearer understanding of how high levels of low-density lipoprotein (LDL) cholesterol can increase the risk of dementia. A meta-analysis involving over a million people found that for every 1 mmol/L increase in LDL cholesterol, there was an 8% increase in the risk of developing dementia The Lancet.
Cholesterol plays a vital role in brain function, as it is a key component of cell membranes and is involved in the production of neurotransmitters. However, excess LDL cholesterol can lead to the buildup of plaques in the arteries, including those that supply blood to the brain. This can result in reduced blood flow, increasing the risk of stroke and contributing to the development of vascular dementia.
In addition, high LDL cholesterol levels are associated with an increased risk of amyloid plaque formation in the brain, a characteristic of Alzheimer's disease. These plaques disrupt communication between neurons and trigger inflammatory responses, leading to cognitive decline.
Managing cholesterol levels is essential for reducing the risk of dementia. Statins, a class of cholesterol-lowering drugs, have shown promise in reducing the risk of all-cause dementia and Alzheimer's disease when used consistently over time. However, the use of statins should be carefully monitored by a healthcare provider, as they may have side effects in some individuals.
Diet and lifestyle modifications can also play a significant role in controlling cholesterol levels. A heart-healthy diet that emphasizes fruits, vegetables, whole grains, and lean proteins can help reduce LDL cholesterol. Incorporating healthy fats, such as those found in olive oil, avocados, and nuts, can also improve cholesterol levels.
Regular exercise is another effective way to manage cholesterol. Physical activity helps raise high-density lipoprotein (HDL) cholesterol, which is known as "good" cholesterol, while lowering LDL cholesterol. Maintaining a healthy weight and avoiding smoking are additional strategies for keeping cholesterol levels in check.
Routine cholesterol screenings are crucial for early detection and management. If you have high cholesterol or are at risk, work with your healthcare provider to develop a personalized plan to manage your levels and protect your brain health.
Weight Management and Diabetes: Crucial Factors
Obesity and diabetes are two interconnected risk factors that significantly increase the likelihood of developing dementia. Central obesity, characterized by a larger waist circumference or higher waist-to-hip ratio, is particularly concerning, as it is closely linked to metabolic disturbances that affect brain health.
A study found that individuals with central obesity had a higher risk of cognitive impairment and dementia, especially in those over 65. Even modest weight loss, such as losing just 2 kilograms, has been shown to improve cognition within six months The Lancet.
Obesity is also a major risk factor for type 2 diabetes, another condition strongly linked to dementia. Diabetes can lead to insulin resistance in the brain, impairing glucose metabolism and leading to the accumulation of toxic proteins associated with Alzheimer's disease. A study found that for every 5-year decrease in the age at which type 2 diabetes is diagnosed, the risk of developing dementia increases by 24% The Lancet.
Managing weight and diabetes is crucial for reducing dementia risk. A balanced diet that emphasizes whole foods, such as fruits, vegetables, lean proteins, and whole grains, can help maintain a healthy weight and regulate blood sugar levels. Avoiding processed foods, sugary beverages, and excessive refined carbohydrates is also important for managing both weight and diabetes.
Incorporating regular physical activity into your routine is essential for weight management and blood sugar control. Exercise helps improve insulin sensitivity, allowing the body to use glucose more effectively. Aim for at least 30 minutes of moderate-intensity exercise most days of the week, combined with strength training exercises to build muscle and boost metabolism.
For individuals with diabetes, monitoring blood sugar levels and adhering to prescribed medications are key components of effective management. Working closely with a healthcare provider to develop a personalized diabetes management plan can help prevent complications and reduce the risk of cognitive decline.
In addition to lifestyle changes, behavioral interventions, such as stress management and adequate sleep, play a role in managing weight and diabetes. Chronic stress and poor sleep can disrupt metabolic processes and contribute to weight gain and insulin resistance.
Blood Pressure Control: A Key to Brain Health
High blood pressure, or hypertension, is a significant risk factor for dementia. It damages blood vessels in the brain, leading to reduced blood flow and increasing the risk of strokes and vascular dementia. A meta-analysis of 12 randomized controlled trials involving over 96,000 participants found that people who took antihypertensive medications had a lower risk of developing dementia or cognitive impairment compared to those who didn't The Lancet.
One of the most significant studies in this area, the SPRINT study, highlighted the importance of maintaining a systolic blood pressure of 120 mmHg or lower. The study found that individuals who maintained this target had a significant reduction in the risk of cardiovascular events and dementia The New England Journal of Medicine.
Managing blood pressure involves a combination of lifestyle changes and medication. A diet rich in fruits, vegetables, whole grains, and low-fat dairy products—commonly known as the DASH diet (Dietary Approaches to Stop Hypertension)—has been proven to lower blood pressure. Reducing sodium intake, limiting alcohol consumption, and avoiding tobacco products are also critical steps in maintaining healthy blood pressure levels.
Regular physical activity, such as aerobic exercise, strengthens the heart and improves circulation, which helps lower blood pressure. Stress management techniques, such as deep breathing, meditation, and yoga, can also reduce blood pressure by promoting relaxation and reducing the body's stress response.
Medication is often necessary for individuals with hypertension to achieve optimal blood pressure control. Antihypertensive medications, such as ACE inhibitors, beta-blockers, and diuretics, are commonly prescribed to manage blood pressure. It's important to take these medications as directed and work with a healthcare provider to monitor their effectiveness and adjust treatment as needed.
Routine blood pressure monitoring at home can help track progress and ensure that levels remain within a healthy range. This proactive approach allows for early detection of any changes and prompt intervention to prevent complications.
Alcohol Consumption: Balancing Risks
The relationship between alcohol consumption and brain health is complex. While moderate alcohol consumption has been associated with some health benefits, excessive drinking is a well-established risk factor for cognitive decline and dementia.
Drinking more than 21 UK units of alcohol per week in midlife is associated with an increased risk of dementia. However, some studies suggest that light-to-moderate drinkers may have a lower risk of dementia compared to non-drinkers. This J-shaped curve, where light drinking seems to offer some protection, might not be as straightforward as it appears The Lancet.
The potential protective effects of alcohol, particularly red wine, are often attributed to polyphenols, such as resveratrol, which have antioxidant and anti-inflammatory properties. These compounds may help protect brain cells from damage and improve cardiovascular health, indirectly benefiting cognitive function.
However, the risks of excessive alcohol consumption far outweigh any potential benefits. Heavy drinking can lead to alcohol-related brain damage (ARBD), which includes a range of cognitive impairments resulting from prolonged alcohol use. Alcohol also disrupts the balance of neurotransmitters, leading to mood disorders, memory problems, and impaired decision-making.
Moreover, alcohol is metabolized by the liver, which produces acetaldehyde, a toxic byproduct that can damage brain cells. Chronic alcohol consumption also increases the risk of developing conditions like liver disease, hypertension, and diabetes, which are all linked to cognitive decline.
For those who choose to drink alcohol, moderation is key. The current guidelines recommend no more than 14 units of alcohol per week for both men and women, with alcohol-free days each week to allow the body to recover. It's also important to spread alcohol consumption evenly over the week, rather than binge drinking.
If you're concerned about your alcohol intake or are at risk for dementia, it may be wise to limit or avoid alcohol altogether. There are many non-alcoholic beverages that offer the same social experience without the health risks, such as sparkling water with a splash of juice, herbal teas, or alcohol-free wine and beer.
Social Connections and Mental Health
Social connections are vital for both mental and physical health. Strong social ties have been shown to reduce the risk of various health issues, including cardiovascular disease, depression, and cognitive decline. Remaining socially active is one of the most effective strategies for reducing the risk of dementia.
Social interactions stimulate the brain by providing opportunities for communication, problem-solving, and emotional support. Engaging in meaningful relationships with family, friends, and community members helps maintain cognitive functions and can protect against the effects of aging on the brain The Lancet.
Loneliness and social isolation, on the other hand, have been linked to an increased risk of cognitive decline and dementia. Individuals who are socially isolated are more likely to experience depression, anxiety, and a decrease in cognitive engagement, all of which contribute to dementia risk.
To build and maintain social connections, it's important to actively seek out opportunities for interaction. Joining clubs, volunteering, participating in community events, and staying in touch with family and friends are all ways to stay socially engaged. For those who may be more introverted or have limited mobility, online communities and social media platforms offer alternative ways to connect with others.
Maintaining social connections becomes increasingly important as we age, especially after retirement when social networks may naturally decrease. It's essential to make an effort to engage in activities that bring joy and foster relationships. This could be as simple as scheduling regular phone calls with loved ones, joining a book club, or participating in group exercise classes.
For caregivers and family members of individuals with dementia, encouraging social interaction is crucial for their cognitive and emotional well-being. Activities that involve group participation, such as music therapy, art classes, and group outings, can provide both cognitive stimulation and social support.
In addition to promoting cognitive health, strong social connections also provide emotional benefits, reducing stress and increasing feelings of happiness and fulfillment. By staying socially active, you can enhance your quality of life and reduce your risk of cognitive decline.]
Reducing Exposure to Air Pollution
Air pollution is a growing concern for public health, and its impact on brain health is becoming increasingly evident. Exposure to high levels of air pollution, particularly fine particulate matter (PM2.5), has been linked to an increased risk of dementia. These tiny particles can penetrate the respiratory system and enter the bloodstream, causing inflammation and oxidative stress that can damage brain cells The Lancet.
Air pollution is particularly harmful to older adults and individuals with preexisting health conditions. Living in areas with high levels of traffic-related pollution or industrial emissions can significantly increase the risk of cognitive decline. Studies have shown that individuals living in highly polluted areas have a higher incidence of dementia compared to those in cleaner environments.
To reduce exposure to air pollution, it's important to take both personal and community-level actions. On a personal level, you can minimize exposure by avoiding outdoor activities during high pollution days, using air purifiers indoors, and keeping windows closed when pollution levels are high. When exercising outdoors, choose routes away from heavy traffic and industrial areas.
Advocating for cleaner environments through community initiatives and supporting policies that aim to reduce emissions can also make a significant difference. Transitioning to renewable energy sources, improving public transportation, and promoting the use of electric vehicles are all steps that can reduce air pollution at a societal level.
Improving indoor air quality is equally important, especially for individuals who spend a lot of time indoors. Using high-efficiency particulate air (HEPA) filters, avoiding the use of tobacco products indoors, and reducing the use of harsh cleaning chemicals can all contribute to a healthier indoor environment.
Finally, being informed about air quality in your area can help you make better decisions about when and where to engage in outdoor activities. Many cities offer real-time air quality monitoring and provide alerts when pollution levels are high. By staying informed and taking proactive steps, you can protect your brain health and reduce the risk of dementia related to air pollution.
Emerging Factors and Future Strategies
As research on dementia continues to evolve, new risk factors and prevention strategies are emerging. One area of interest is the role of sleep duration in cognitive health. While the science isn't settled yet, there is evidence to suggest that both too little and too much sleep can be linked to cognitive decline and dementia The Lancet.
Sleep plays a crucial role in brain health, as it is during sleep that the brain clears out toxins and consolidates memories. Disruptions in sleep patterns, such as sleep apnea or insomnia, can impair these processes and contribute to cognitive decline. Ensuring adequate and quality sleep is therefore an important consideration in dementia prevention.
Another emerging area of research is the potential link between multivitamin and mineral supplements and brain health. The large COSMOS studies are investigating whether these supplements can reduce the risk of cognitive decline and dementia. While the results are still pending, future research may add these supplements to the list of dementia prevention strategies.
Gut health and the microbiome are also gaining attention as potential contributors to brain health. The gut-brain axis, the communication pathway between the gut and the brain, plays a role in regulating inflammation, immunity, and mood, all of which can impact cognitive function. Maintaining a healthy gut through a balanced diet rich in fiber, probiotics, and prebiotics may support brain health and reduce dementia risk.
Looking ahead, advancements in science and technology hold promise for new dementia prevention strategies. Neuroprotective drugs, gene therapy, and personalized medicine approaches are being explored as potential ways to delay or prevent the onset of dementia. Early detection through biomarkers and advanced imaging techniques could also enable more targeted interventions before significant cognitive decline occurs.
Conclusion: Taking Action Now
Addressing the factors discussed in this post can reduce your risk of dementia by up to 45%.
While it's ideal to start making these changes early in life, it's never too late to begin. Whether you're in your 30s, 50s, or 90s, taking steps now can make a significant impact on your long-term brain health.
By focusing on education, cognitive stimulation, hearing and vision care, mental health, exercise, safety, smoking cessation, cholesterol management, weight control, blood pressure management, alcohol moderation, social engagement, and reducing exposure to air pollution, you can take control of your brain health and reduce your risk of dementia.
These strategies are not just about reducing the risk of dementia; they are about living a healthier, more fulfilling life. Small, consistent changes in your daily habits can lead to significant improvements in your overall well-being and cognitive function.
Remember, the journey to better brain health is a marathon, not a sprint. Start by making one change at a time, and gradually build on these efforts. The investment you make in your brain health today will pay dividends in the years to come.
References
- Alzheimer's Society. Risk factors for dementia. Available at: https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/risk-factors-for-dementia
- The Lancet. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Available at: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/fulltext
- SPRINT Study. A randomized trial of intensive versus standard blood-pressure control. New England Journal of Medicine. Available at: https://www.nejm.org/doi/full/10.1056/nejmoa1511939